Two sample MR report
RPS26_T Proliferating against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0285211 | 0.1011968 | 0.7920481 |
| Weighted median | 6 | -0.0594184 | 0.0127103 | 0.0000029 |
| Inverse variance weighted | 6 | -0.0548041 | 0.0100307 | 0.0000000 |
| Simple mode | 6 | -0.0640142 | 0.0185054 | 0.0180576 |
| Weighted mode | 6 | -0.0622708 | 0.0172838 | 0.0154967 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.879205 | 4 | 0.757964 |
| Inverse variance weighted | 1.947329 | 5 | 0.856384 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0129081 | 0.0494551 | 0.8069744 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003666 | 0 | TRUE | 0.0708448 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
